Researchers at the Dana-Farber Cancer Institute may have the best news for couch potatoes since the invention of the Thighmaster — a newly identified hormone that changes white fat cells into brown fat cells, reports Technology Review's Karen Weintraub. The naturally occurring hormone "acts like exercise on muscle tissue," Weintraub says, by burning calories and improving the body's ability to process insulin.

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The US Food and Drug Administration has approved Alnylam's RNAi-based therapy Onpattro, according to Stat News.

Harvard Medical School's Seth Cassel and Cigall Kadoch argue in a Baltimore Sun op-ed that the recent TAILORx trial shows the potential of genomic-based medicine.

Researchers in the UK are working on using gene drives to control malaria-carrying mosquitoes, the Telegraph reports.

In PLOS this week: genetic architecture mediating gene expression, metabolomic patterns in multiple myeloma, and more.