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So More Complicated Than Using a Food Processor?

The Scientist chats with Elaine Mardis, George Church, Andy Gnirke, Hanlee Ji, and Jonathan and Christine Seidman about their preferred methods to fractionate DNA bound for exon sequencing or genome partitioning in next-gen sequencers. Church uses padlock probes while the Seidmans prefer surface capture-based hybridization. "Being able to design a genome-unique set of capture probes or PCR products is not always as easy as it sounds," Mardis adds.

The Scan

Missed Early Cases

A retrospective analysis of blood samples suggests early SARS-CoV-2 infections may have been missed in the US, the New York Times reports.

Limited Journal Editor Diversity

A survey finds low diversity among scientific and medical journal editors, according to The Scientist.

How Much of a Threat?

Science writes that need for a provision aimed at shoring up genomic data security within a new US bill is being questioned.

PNAS Papers on Historic Helicobacter Spread, Brain Development, C. difficile RNAs

In PNAS this week: Helicobacter genetic diversity gives insight into human migrations, gene expression patterns of brain development, and more.