The Scientist chats with Elaine Mardis, George Church, Andy Gnirke, Hanlee Ji, and Jonathan and Christine Seidman about their preferred methods to fractionate DNA bound for exon sequencing or genome partitioning in next-gen sequencers. Church uses padlock probes while the Seidmans prefer surface capture-based hybridization. "Being able to design a genome-unique set of capture probes or PCR products is not always as easy as it sounds," Mardis adds.
So More Complicated Than Using a Food Processor?
May 19, 2009