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So More Complicated Than Using a Food Processor?

The Scientist chats with Elaine Mardis, George Church, Andy Gnirke, Hanlee Ji, and Jonathan and Christine Seidman about their preferred methods to fractionate DNA bound for exon sequencing or genome partitioning in next-gen sequencers. Church uses padlock probes while the Seidmans prefer surface capture-based hybridization. "Being able to design a genome-unique set of capture probes or PCR products is not always as easy as it sounds," Mardis adds.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.