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So Complex

Newsweek discusses some of "life's complexities," namely epigenetics and systems biology.

One article takes a look at epigenetics and its role in cancer. A few epigenetic cancer drugs have been approved by FDA, such as Vidaza and Zolinza, but "first-generation epigenetic drugs have not included a home run like Gleevec," the story says.

In that same issue, Lee Hood describes his vision of P4 medicine — predictive, personalized, preventive, and participatory. Soon, he says, with just a pinprick of blood, thousands of tests may be run and the results sent to both the patient and the doctor. "The new P4 medicine will eventually lead to a universal democratization of health care, bringing to billions the fundamental right of health, unimaginable even a few years ago," Hood writes. He points out, though, that to reach this goal, changes will have to be made to medical education, research, and to the insurance and pharmaceutical industries.

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.