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A SNP for Hepatitis C

Duke's David Goldstein and colleagues found a SNP associated with people's response to treatment for hepatitis C — the treatment is more successful in European-American than in African-Americans. The SNP, they report in an advance online publication of Nature, is located near interferon-lambda-3. "Given that the polymorphism appears to associate with natural clearance as well as treatment response, it seems likely that the gene product is involved in the innate control of HCV," the researchers write. The study was financed by Schering-Plough, which will own the IP on any diagnostic test resulting from the paper, adds the New York Times.

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.