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The Slow Transition

Washington University in St. Louis' Dan Koboldt blogs about their transition from a capillary-based to a massively parallel sequencing platform. They formed a focus group to look at the different programs for aligning and detecting variants in next-gen sequence data and have decided to test five or six of them with data from the work they've done on the 1000 Genomes Project. Those aligners being tested include Maq, Eland, BLAT, and cross_match.