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The Slow Revolution

Though the cost of whole-genome sequencing is falling dramatically, the University of Alberta's Timothy Caulfield writes in the Globe and Mail that having people's full genome sequences might not have as great an effect on their health as has been indicated. "The relationship between our genome and disease is far more complicated than originally anticipated. Indeed, the more we learn about the human genome, the less we seem to know," he writes.

Caulfield points out that many findings from people's genomes, with the exception of rare, single-gene diseases, aren't predictive, especially for common diseases. Oftentimes, he adds, nothing can be done with the information that is gleaned as pharmacogenetic efforts are moving at a slower pace.

"For more than two decades, we've been told that we're in the midst of a genetic revolution. I'm still waiting," he says. "Meantime, if we really want to revolutionize our health, we should all put down the gene sequencers, fries and pop, pick up an apple and go for a brisk walk."

The Scan

Booster Push

New data shows a decline in SARS-CoV-2 vaccine efficacy over time, which the New York Times says Pfizer is using to argue its case for a booster, even as the lower efficacy remains high.

With Help from Mr. Fluffington, PurrhD

Cats could make good study animals for genetic research, the University of Missouri's Leslie Lyons tells the Atlantic.

Man Charged With Threatening to Harm Fauci, Collins

The Hill reports that Thomas Patrick Connally, Jr., was charged with making threats against federal officials.

Nature Papers Present Approach to Find Natural Products, Method to ID Cancer Driver Mutations, More

In Nature this week: combination of cryogenic electron microscopy with genome mining helps uncover natural products, driver mutations in cancer, and more.