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The Silencing of Dox

PLoS Biology has new papers from David Hartl's lab at Harvard University that looks into sex ratio distortion in Drosophila, finding an X-linked sex-ratio distorter called Dox and its dominant suppressor, Nmy. The researchers suggest that small interfering RNAs, made from the Nmy hairpin region, silence Dox. In a related Primer, Cornell's Patrick Ferree and Daniel Barbash write, "This first mechanistic glimpse of a sex-ratio distortion system provided by Tao and colleagues suggests that RNAi-mediated regulation, and its failure, may have important implications for understanding fundamental problems in evolutionary genetics and speciation."

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.