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The Silencing of Dox

PLoS Biology has new papers from David Hartl's lab at Harvard University that looks into sex ratio distortion in Drosophila, finding an X-linked sex-ratio distorter called Dox and its dominant suppressor, Nmy. The researchers suggest that small interfering RNAs, made from the Nmy hairpin region, silence Dox. In a related Primer, Cornell's Patrick Ferree and Daniel Barbash write, "This first mechanistic glimpse of a sex-ratio distortion system provided by Tao and colleagues suggests that RNAi-mediated regulation, and its failure, may have important implications for understanding fundamental problems in evolutionary genetics and speciation."

The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.