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By switching off the BCL11A gene, researchers at Harvard Medical School succeeded in eliminating sickle cell disease in mice, reports New Scientist's Charlie Harvey. The gene is responsible for switching the body's hemoglobin from the fetal form to the adult form, and since it's a mutant form of adult hemoglobin that causes the disease, knocking out BCL11A tricks the body into making fetal hemoglobin, and eliminates the condition, he adds.

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A small, early-stage trial of a combination therapy for brain cancer reports favorable responses in two patients, according to the Guardian.

Nature News writes that viral genomic surveillance in the US faces systemic issues.

President Joe Biden is seeking an increase in federal spending, including higher budgets for the National Institutes of Health and Centers for Disease Control and Prevention.

In PLOS this week: sex-stratified genome-wide association study of chronic pain, sequencing data from Indigenous Mexican groups, and more.