Short and Sticky Does the Trick

Oct 10, 2007

Making siRNAs "gene-like" increases their stability, French biologists report in this week's Proceeding of the National Academy of Sciences. The researchers added short, complementary A5–8/T5–8 3' overhangs to siRNAs, creating sticky overhangs, and called the product ssiRNAs. The added stability upped their RNase protection and in vitro gene silencing by 10-fold.

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