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Sheesh, Now You Want to Know How It Works, Too?

Pharmacogenomics is changing how drugs will have to be evaluated, says Russ Altman at his Building Confidence blog. On the plus side, he writes, we have a better understanding of the biology involved since PGx is based on comprehensive studies of genomics. But our lack of clarity on most compounds' mechanism of action is still a hindrance. "There needs to be an investment in drug mechanism," he writes. "It will make the pharmacogenetic task easier, but will also lead to a more profound understanding of how drugs work and how new drugs may work better."

 

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.