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Sequencing Companies Serving Niche Markets

Discussions of Dan Koboldt's recent blog post outlining "Next-Gen Sequencing in 2010," are reverberating throughout the blogosphere: BNET picked up his post and Daniel MacArthur has contributed his thoughts on the state of sequencing technologies, post-AGBT meeting. Kobolt suggests that, in stark contrast to the disposition of the sequencing powerhouses in 2009 ― "every player was gunning to take over the world" ― companies now appear to have "a niche in mind." In the "general sequencing" category, Koboldt writes, it remains Illumina versus Life Technologies. Roche/454 platforms cater to researchers seeking long-read sequencing runs, while Complete Genomics is still the frontrunner in "sequencing as a service." This year's debut of the Ion Torrent sequencing machine introduces what Koboldt calls "sequencing for the masses," while Pacific Biosciences and Oxford Nanopore are focusing on targeted applications.

The Scan

Genome Sequences Reveal Range Mutations in Induced Pluripotent Stem Cells

Researchers in Nature Genetics detect somatic mutation variation across iPSCs generated from blood or skin fibroblast cell sources, along with selection for BCOR gene mutations.

Researchers Reprogram Plant Roots With Synthetic Genetic Circuit Strategy

Root gene expression was altered with the help of genetic circuits built around a series of synthetic transcriptional regulators in the Nicotiana benthamiana plant in a Science paper.

Infectious Disease Tracking Study Compares Genome Sequencing Approaches

Researchers in BMC Genomics see advantages for capture-based Illumina sequencing and amplicon-based sequencing on the Nanopore instrument, depending on the situation or samples available.

LINE-1 Linked to Premature Aging Conditions

Researchers report in Science Translational Medicine that the accumulation of LINE-1 RNA contributes to premature aging conditions and that symptoms can be improved by targeting them.