Sequence Alignment in Six Easy Steps | GenomeWeb

At his blog, Buried Treasure, Lars Juhl Jensen discusses two papers that point out possible mistakes in the current, and commonly used, sequence alignment techniques. The papers, published in Science and Nature Biotechnology, describe how uncertainties in multiple alignments can lead to errors in different phylogenetic trees, and discover that the most commonly used substitution matrix, BLOSUM62, was calculated wrongly.

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