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Seeing the Rearrangements

In Genome Research, Baylor College of Medicine researchers made a sequence-level chromosomal map of the MCF-7 breast cancer cell line to study its chromosomal rearrangements. Using end-sequence profiling and massively parallel sequencing, they analyzed the chromosomal breakpoints and rearrangements. They identified 79 genes involved in these events, some of which appear to be tumor-suppressor genes or genome stability genes, including BRIP1 and RAD51C. The New York Times reprinted the visualization of the rearrangements here.

 

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.