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Seeing the Rearrangements

Dec 29, 2008

In Genome Research, Baylor College of Medicine researchers made a sequence-level chromosomal map of the MCF-7 breast cancer cell line to study its chromosomal rearrangements. Using end-sequence profiling and massively parallel sequencing, they analyzed the chromosomal breakpoints and rearrangements. They identified 79 genes involved in these events, some of which appear to be tumor-suppressor genes or genome stability genes, including BRIP1 and RAD51C. The New York Times reprinted the visualization of the rearrangements here.

 

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