Researchers from the J. Craig Venter Institute and the Ludwig Cancer Institute identified genomic rearrangements in a breast cancer cell line using high-throughput transcriptome sequencing. They used 454 Life Sciences sequencing to identify those rearrangements. The gene fusions and truncations they noted included ones that affected the MRE11 and NSD1 genes, which are already known to be involved in oncogenesis. Their work appears in the current issue of PNAS.
Searching the Transcriptome
Feb 12, 2009