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Searching for Recurrent Mutations

Elaine Mardis and her colleagues at Washington University in St. Louis sequenced the genome of a man with acute myeloid leukemia using Illumina's Genome Analyzer II and identified 64 mutations, according the report in the New England Journal of Medicine. Of those, 12 were somatic mutations in coding regions and 52 were somatic point mutations in conserved or regulatory regions. Four of the mutations also occurred in at least one other AML sample that had also been tested and two of these were already known mutations. In a statement, senior author Timothy Ley says, "Only by sequencing complete genomes of cancer patients are we going to find unexpected, recurring genetic mutations that are highly likely to be important for cancer to develop and grow."

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.