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Search Spit for Signs of Aging

By comparing the salivary proteomes of younger and older women, John Yates and his colleagues find that protein expression is age-dependent. As they report in the Journal of Proteome Research, they fractionated parotid saliva from 14 women and then analyzed the samples using mass spec and MudPIT. They identified 532 proteins, but found that half were only expressed in a particular age group. "It is critical to take into consideration these normal differences in protein expression when searching for clinically relevant, disease specific biomarkers," the authors write. In a related news story, author James Melvin adds, "Because several diseases that affect women, in particular autoimmune disorders, are age-dependent, we wanted to determine the background levels of protein changes that you'd expect to see in normal aging."

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.