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Search Spit for Signs of Aging

By comparing the salivary proteomes of younger and older women, John Yates and his colleagues find that protein expression is age-dependent. As they report in the Journal of Proteome Research, they fractionated parotid saliva from 14 women and then analyzed the samples using mass spec and MudPIT. They identified 532 proteins, but found that half were only expressed in a particular age group. "It is critical to take into consideration these normal differences in protein expression when searching for clinically relevant, disease specific biomarkers," the authors write. In a related news story, author James Melvin adds, "Because several diseases that affect women, in particular autoimmune disorders, are age-dependent, we wanted to determine the background levels of protein changes that you'd expect to see in normal aging."

The Scan

CDC Calls Delta "Variant of Concern"

CNN reports the US Centers for Disease Control and Prevention now considers the Delta variant of SARS-CoV-2 to be a "variant of concern."

From FDA to Venture Capital

Former FDA Commissioner Stephen Hahn is taking a position at a venture capital firm, leading some ethicists to raise eyebrows, according to the Washington Post.

Consent Questions

Nature News writes that there are questions whether informed consent was obtained for some submissions to a database of Y-chromosome profiles.

Cell Studies on Multimodal Single-Cell Analysis, Coronaviruses in Bats, Urban Microbiomes

In Cell this week: approach to analyze multimodal single-cell genomic data, analysis of bat coronaviruses, and more.