Search for the Cause

After two years of not-quite-right diagnoses, Matt and Cristina Might enrolled their son in a genome sequencing study aimed at finding the genetic basis of rare diseases, the New Yorker's Seth Mnookin reports. Bertrand Might, as Mnookin describes, suffers from movement issues, seizures, and the inability to make tears, among other symptoms.

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Researchers hope to tease out the signature effects that different carcinogens leave on the genome to determine their contributions to disease, Mosaic reports.

The Wall Street Journal looks into the cost of new gene therapies.

An Imperial College London-led team reports that it was able to use a gene drive to control a population of lab mosquitos.

In PNAS this week: genomic effects of silver fox domestication, limited effect of mitochondrial mutations on aging in fruit flies, and more.