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Science Agenda in the House

US Representative Bart Gordon (D–TN), who chairs the House Science and Technology Committee, mapped out his 2010 legislative agenda, according to ScienceInsider (However, as ScienceInsider says, Gordon has “a legislative batting average that would make a Little Leaguer blush.”) At the top of the agenda is reauthorizing the 2007 America COMPETES Act, which increased the research budgets at DOE, NIST, and NSF and created the Advanced Research Projects Agency-Energy. Gordon expects minor changes to the act. He also says that he doesn’t expect 2011 to hold the same funding increases as 2010. "You have to recognize the [current] economic reality," says Gordon. "Any type of significant increase will be a victory. ... I'd like to see it above inflation, as a minimum. But I think that 7 percent is the right number."

The Scan

Single-Cell Sequencing Points to Embryo Mosaicism

Mosaicism may affect preimplantation genetic tests for aneuploidy, a single-cell sequencing-based analysis of almost three dozen embryos in PLOS Genetics finds.

Rett Syndrome Mouse Model Study Points to RNA Editing Possibilities

Investigators targeted MECP2 in mutant mouse models of Rett syndrome, showing in PNAS that they could restore its expression and dial down symptoms.

Investigators Find Shared, Distinct Genetic Contributors to Childhood Hodgkin Lymphoma

An association study in JAMA Network Open uncovers risk variants within and beyond the human leukocyte antigen locus.

Transcriptomic, Epigenetic Study Appears to Explain Anti-Viral Effects of TB Vaccine

Researchers report in Science Advances on an interferon signature and long-term shifts in monocyte cell DNA methylation in Bacille Calmette-Guérin-vaccinated infant samples.