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Scary Yet Cool

This New Yorker story looks into synthetic biology, particularly the work of Berkeley's Jay Keasling and Stanford's Drew Endy. Both say that one goal of their work is to make interchangeable parts that can be swapped in and out of a cell — like a hard drive, as Keasling puts it. However, some of what is proposed, namely creating new forms of life or designing children, gives people pause. Why? "Because it's scary as hell," Endy says. "It's the coolest platform science has ever produced, but the questions it raises are the hardest to answer."

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.