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Saying Goodbye

Rick Carlson, a health consultant and one of the people behind the Health Maintenance Organization program, died of a heart attack February 13th, according to the Aspen Daily News. Carlson drafted the legislation sparking the HMO movement while at the Institute of Interdisciplinary Studies (now InterStudy) in Minneapolis and more recently would say that he was still trying to live that down. Jason Bobe is mourning the loss of Carlson, who he calls one of his "most valued advisors." Carlson was going to be a guest blogger for Bobe and Bobe has posted the essay Carlson was working on that discusses policy issues surrounding consumer genomics. "The potential benefits are exciting and immense, but along the way, society will have to digest a stew of disruptive social, cultural and economic uncertainties," Carlson wrote.

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The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.