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Sall4 in Embryonic Development

Researchers at the Nevada Cancer Institute in Las Vegas found that Sall4, a zinc-finger transcription factor that is expressed very early in embryonic development with Oct4 and Nanog, plays a diverse role in regulating stem cell pluripotency during early embryonic development. Using chIP-chip analysis to map genome-wide gene targets of Sall4 in mouse ES cells, they found that the protein bound 3,223 genes, many of which have major functions in developmental and regulatory pathways. They published their results yesterday in PNAS.

The Scan

Could Cost Billions

NBC News reports that the new Alzheimer's disease drug from Biogen could cost Medicare in the US billions of dollars.

Not Quite Sent

The Biden Administration likely won't meet its goal of sending 80 million SARS-CoV-2 vaccine doses abroad by the end of the month, according to the Washington Post.

DTC Regulation Proposals

A new report calls on UK policymakers to review direct-to-consumer genetic testing regulations, the Independent reports.

PNAS Papers on Mosquito MicroRNAs, Acute Kidney Injury, Trichothiodystrophy

In PNAS this week: microRNAs involved in Aedes aegypti reproduction, proximal tubule cell response to kidney injury, and more.