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Running Around the CDC

A year into leading the Center for Disease Control and Prevention, Thomas Frieden "has quietly scrapped nearly all the administrative changes that the previous director, Dr. Julie L. Gerberding, spent much of her six-year tenure conceiving and carrying out," says the New York Times. Among Frieden's priorities is improving the center's ability to track disease and support local governments as well as encouraging people to quit smoking and get treatment for high blood pressure. "I think he's doing a great job," former CDC director Jeffrey Koplan tells the Times. "He is setting priorities and sticking to them."

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.