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Fungal Attacks on Amphibians

In the PNAS Early Edition this week, researchers at San Francisco State University and the Univeristy of California, Berkeley, implicate the fungal pathogen Batrachochytrium dendrobatidis as a key contributor to the decline of certain amphibian species. Using a non-invasive sampling technique on formalin-preserved museum specimens "collected before, during, and after major amphibian decline events" followed by real-time PCR, the team detected "a pattern of Bd emergence coincident with decline," the team reports. Tina Cheng, lead author on the study, tells the San Francisco Chronicle that "what's so alarming is that Bd attacks so many species that some are now close to becoming extinct." Cheng and her team have tested more than 1,000 specimens to date, and she adds that they plan to document the spread of the disease going forward.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.