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The Round of 100

Daniel MacArthur at Genetic Future blogs about the news that George Church's Personal Genome Project "has called for the next wave of volunteers." This round will include 100 people who will get their genome sequenced (at no cost to them). "The benefits to volunteers are straightforward: you get access to your own genome sequence before most human beings on the planet, and you get the warm fuzzy glow that comes with benefiting humanity," MacArthur writes.

He adds that volunteering is not for the faint of heart: "Volunteering to participate is not simply a matter of filling in a few forms: the PGP takes the notion of 'informed consent' to a new level, requiring that you prove just how informed you are by taking an entrance test that assesses your 'comprehension of concepts relevant to providing informed consent to participate in the PGP' including 'concepts such as potential risks of participating, project protocols, and basic genetics.'"

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.