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A Proposal

Ron Paul (R-Tx.) released a new proposal to cut federal spending for research in a budget plan he says he will enact if elected president of the US in 2012, reports ScienceInsider's Jeffrey Mervis. The proposal "would wipe out large chunks of the government's research portfolio," Mervis says, erasing such programs as the Energy Department's $5 billion Office of Science, the $4.5 billion National Oceanic and Atmospheric Administration, and the US Geological Survey, among others. "Paul would also end funding for all research programs at the US Department of Agriculture, although the department itself would be preserved at its current budget. And he would pare roughly $7 billion from the current $30 billion budget for the National Institutes of Health," Mervis adds. The plan says nothing about the National Science Foundation.

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.