Adaptive Complexity awards a report card on genome-wide association studies, saying they work well for some traits, but not all. The post points to a recent paper in Nature Reviews Genetics that says GWAS have been useful in identifying SNPs that have a decent-sized impact on phenotype, but that they are thus far unable to explain multifactorial traits. The reviewers also say that the data from GWAS should be widely available. "We should get as much mileage out of them as possible, by doing what publicly funded scientists should do anyway: share data," adds the blog post.
May 20, 2008