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At Bitesize Bio, Rob offers tips for performing restriction digests. "Restriction digests are simple. But underestimate them at your peril," says Rob. Before running your screen, you should make a list of the available enzymes (avoid "unfriendly" ones) and identify restriction sites in both the insert and vector. He also offers a checklist of reasons the screen might have gone wrong.

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The UK and the European Union have come to a sticking point in the negotiation of how the UK might remain involved in the Horizon Europe research program, the Guardian reports.

The New York Times reports that experts pushed during a meeting of an FDA advisory board for the agency to require more safety data from SARS-CoV-2 vaccine trials.

The Washington Post reports Moderna expects that it will have enough data on its candidate SARS-CoV-2 vaccine to submit to regulatory authorities by mid-November.

In Science this week: ANXA11 variants affect calcium homeostasis and stress granule disassembly in ALS, and more.