At Bitesize Bio, Rob offers tips for performing restriction digests. "Restriction digests are simple. But underestimate them at your peril," says Rob. Before running your screen, you should make a list of the available enzymes (avoid "unfriendly" ones) and identify restriction sites in both the insert and vector. He also offers a checklist of reasons the screen might have gone wrong.

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Senator Elizabeth Warren (D-Mass.) has released the results of a genetic ancestry analysis, the Boston Globe reports.

Retraction Watch's Ivan Oransky and Adam Marcus report that Harvard Medical School and Brigham and Women's Hospital have recommended that more than 30 papers from a former researcher be retracted.

Thomas Steitz, who won the 2009 chemistry Nobel Prize for his ribosome work, has died, the Washington Post reports.

In PLOS this week: mechanisms for genes implicated in coronary artery disease, rumen microbes and host genetics influence cow methane production, and more.