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"Researchers at Work"

The New York Times reviews a new addition to the Darwin Center at the Natural History Museum in London, saying there is "something daring, almost provocative, about the Cocoon." The new exhibition space is, indeed, a cocoon-like structure eight stories tall and, in it, the Times says the museum "humanizes scientific research, stressing that it is an inquiry conducted by curious individuals who undertake strenuous labors before reaching insight." The review adds is taken a bit far and the exhibit becomes "creepy" when the visitors can watch museum researchers at work through a window. The review concludes that "what the Cocoon fully succeeds in doing is teaching us that the collections found in the museum's older halls are themselves reflections of curiosity, compulsion and analysis, that they were laid out because of arguments being made."

The Scan

Expanded Genetic Testing Uncovers Hereditary Cancer Risk in Significant Subset of Cancer Patients

In Genome Medicine, researchers found pathogenic or likely pathogenic hereditary cancer risk variants in close to 17 percent of the 17,523 patients profiled with expanded germline genetic testing.

Mitochondrial Replacement Therapy Embryos Appear Largely Normal in Single-Cell 'Omics Analyses

Embryos produced with spindle transfer-based mitochondrial replacement had delayed demethylation, but typical aneuploidy and transcriptome features in a PLOS Biology study.

Cancer Patients Report Quality of Life Benefits for Immune Checkpoint Inhibitors

Immune checkpoint inhibitor immunotherapy was linked in JAMA Network Open to enhanced quality of life compared to other treatment types in cancer patients.

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.