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Researchers Discover Three Genes Linked to Clotting

In a study in the American Journal of Human Genetics, researchers at the University of Edinburgh say they've discovered three genes that make a substantial contribution to blood-clotting times. The team, led by Ian Deary, says identifying the genes could further scientists' understanding of deep vein thrombosis, heart attacks, and some types of stroke. The study looked for associations between 500,000 genetic markers and clotting time, measured by activated partial thromboplastin time. Three genes — F12, HRG, and KNG1 — seemed to be responsible for a substantial amount of the variation in clotting speed among healthy individuals. Deary says the researchers are planning to follow up on the findings to establish their clinical significance.

The Scan

Highly Similar

Researchers have uncovered bat viruses that are highly similar to SARS-CoV-2, according to Nature News.

Gain of Oversight

According to the Wall Street Journal, the Biden Administration is considering greater oversight of gain-of-function research.

Lasker for mRNA Vaccine Work

The Scientist reports that researchers whose work enabled the development of mRNA-based vaccines are among this year's Lasker Award winners

PLOS Papers on Causal Variant Mapping, Ancient Salmonella, ALK Fusion Test for NSCLC

In PLOS this week: MsCAVIAR approach to map causal variants, analysis of ancient Salmonella, and more.