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Reliability, Schmiability

Daniel MacArthur points out that 23andMe seems to be testing people for rare variants associated with Parkinson's disease and he wonders why those results (the company noted recently that it hasn't found anyone with those variations) haven't been reported back to the customers. He's guessing that they are concerned about the reliability of the results. "Screening for extremely rare variants is tricky for two reasons: firstly, since there are very few individuals around who carry the mutation, obtaining positive controls is difficult; and secondly, screening accuracy needs to be extremely high to keep down the rate of false positives," he writes. He adds that this is a sign that 23andMe is interested in moving into the clinical arena.

In other personal genomics news, if you've been suspecting you have warrior ancestry, Warrior Roots would be glad to take your money (if you're male, that is -- the test looks at the Y chromosome) and tell you what warrior clan you come from.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.