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Rejection Hurts

A new study published in Nature is giving researchers pause as they consider the usefulness of induced pluripotent stem cells in treating disease, says The New York Times' Andrew Pollack. The study reports that tissues made from iPS cells may be rejected by a patient's immune system — even tissues derived from cells from the same patient, Pollack says. Although it is unclear whether these results from mice will hold true in humans, experts say they are nonetheless surprised, and that it will now be more difficult to take stem cells to the clinic. The University of California, San Diego, researchers who conducted the study found no immune response to implanted embryonic stem cells, but their immune systems "attacked" iPS cells, Pollack says. "Further experiments suggested that the reaction was caused by the abnormal activation of certain genes in the iPS cells, resulting in the production of proteins that seemed foreign to the immune systems of the mice," he adds.

The Scan

US Booster Eligibility Decision

The US CDC director recommends that people at high risk of developing COVID-19 due to their jobs also be eligible for COVID-19 boosters, in addition to those 65 years old and older or with underlying medical conditions.

Arizona Bill Before Judge

The Arizona Daily Star reports that a judge is weighing whether a new Arizona law restricting abortion due to genetic conditions is a ban or a restriction.

Additional Genes

Wales is rolling out new genetic testing service for cancer patients, according to BBC News.

Science Papers Examine State of Human Genomic Research, Single-Cell Protein Quantification

In Science this week: a number of editorials and policy reports discuss advances in human genomic research, and more.