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When preparing revisions to an NIH grant application, DrugMonkey says "one of the best starting places … is to think about the review process." For example, an investigator who plans to revise and resubmit should consider that his or her grant will "in most cases … go back to the same study section," DrugMonkey says, and, as such, it will likely be reviewed by someone who has already seen it. Further, he adds, the reviewers — whether new or old — "will see the summary statement from the prior review, but not the application itself," necessitating careful attention to how the investigator words his or her "introduction to the revised application" section. "You should start off with a sentence to the effect of 'This is a revision of IC031666 reviewed in Panel VWXYNot in Feb of 2011 where it received a priority score of 31 and a percentile rank of 26 percent,'" while avoiding the natural inclination to "reiterate some of the more glowing and approving comments made by the reviewers," DrugMonkey says. It's also important, he adds, to resist the urge to criticize the grant's prior reviewers, as "this doesn't go well." The remainder of the revised grant should list "the most-important and/or most-consistent criticisms, one by one, with your reply underneath," DrugMonkey says, suggesting that the applicant "edit this down to a few phrases that communicate the point and combine the same criticism from multiple reviewers if applicable." Overall, he says, "the quality of your response to the prior criticism is a major factor in review."

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.