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From the Rare to the Ordinary

As sequencing becomes ever cheaper, genome profiling will move from being used in the clinic in cases of rare diseases to more everyday health issues, says Amy Dockser Marcus in The Wall Street Journal. "Whole-genome sequencing will not stay confined to extremely rare cases of obscure diseases," says Robert Green from Brigham and Women's Hospital and Harvard Medical School. "If there is a way to use sequencing in day-to-day medicine, we need to find out." However, as Marcus notes, some experts say that sequencing patients will be of little use, especially for diseases like diabetes, where many genes may contribute to the condition, and some patients might not want to know if they are at higher risk for disease.

In a related blog post, Marcus discusses incidental findings from such genetic screens. Some geneticists advise to only return results that are medically actionable, while others say a broader range of results should be returned. Marcus adds that the American College of Medical Genetics and Genomics is working on drawing up a list of conditions about which labs should return results.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.