Logo

Quantitative Phosphoproteomics: Don't Try Saying This at Home

Feb 14, 2008

Matthias Mann and colleagues at the Max Planck Institute of Biochemistry have published an open access paper in PNAS this week in which they defined the tyrosine-phosphoproteome of the insulin signaling pathway. They used a combination of high res mass spec and phosphotyrosine immunoprecipitation and stable isotope labeling by amino acids in cell culture (SILAC) to conduct their "quantitative phosphoproteomic" work, finding seven previously unidentified proteins involved, as well as that the pathway is connected to calcium signaling.

Breaking News
The Scan

Billions for Antivirals

The US is putting $3.2 billion toward a program to develop antivirals to treat COVID-19 in its early stages, the Wall Street Journal reports.

NFT of the Web

Tim Berners-Lee, who developed the World Wide Web, is auctioning its original source code as a non-fungible token, Reuters reports.

23andMe on the Nasdaq

23andMe's shares rose more than 20 percent following its merger with a special purpose acquisition company, as GenomeWeb has reported.

Science Papers Present GWAS of Brain Structure, System for Controlled Gene Transfer

In Science this week: genome-wide association study ties variants to white matter stricture in the brain, and more.