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The Prospects

With news of the launch of Pacific Biosciences' SMRT machine, Keith Robison at Omics! Omics! takes a minute to blog about the company. There are few challenges that the company faces, he says, and the main one is meeting demand for machines. "The system has three salient positive characteristics which can sell machines: extremely long reads, relatively fast sample-to-sequence time, and the ability to directly detect modified or non-canonical bases. Then it has two huge handicaps: the pricetag and the low (~80%) single-pass accuracy (the monster size and weight aren't a plus, but if you really need a machine you'll create the space!)," Robison writes. One way that Robison says PacBio can help itself out is by publishing more papers to show the variety of projects the machine can be useful for.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.