National Cancer Institute researchers report that, in their mouse study, breast cancer gene expression signatures were "consistently predictive" of metastasis. As they report in Cancer Research, the scientists conducted a series of gene expression profiling experiments and saw that the signature is combination of genes expressed in all tissues as well as from the tumor epithelium and somatic mutations. "Hopefully, in the future, we will be able to determine which women are more likely to have a tumor that would metastasize, and we could then tailor therapy specifically for them, avoiding the use of harsh treatments for those with a low probability of metastasis," study author Kent Hunter says.
Prognosis Predictions for Breast Cancer
Jan 03, 2009