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Price? Cost? Whatever...

Mike the Mad Biologist came across a Nature Reviews Genetics article that says that hundreds of gigabases of sequencing data can be generated in a week "for less than US$5,000." Mike says could be true, with a lot of caveats. Buying a machine, he says, would be at least $500,000 and, if amortized over about two years, that could come out to be about $5,000 per 200Gb. In addition there's the cost of paying people to run those machines, which he arbitrarily puts at $150,000 per year for two people. "I'm willing to go along with the costs of reagents plus minimal ancillary costs, such as electricity, running around $5,000. Maybe," Mike says. "And if that's all you have to write your purchase or billing order for, then the price of sequencing is around $5,000. But the cost, including the externalized costs, is much more."

The Scan

Study Finds Sorghum Genetic Loci Influencing Composition, Function of Human Gut Microbes

Focusing on microbes found in the human gut microbiome, researchers in Nature Communications identified 10 sorghum loci that appear to influence the microbial taxa or microbial metabolite features.

Treatment Costs May Not Coincide With R&D Investment, Study Suggests

Researchers in JAMA Network Open did not find an association between ultimate treatment costs and investments in a drug when they analyzed available data on 60 approved drugs.

Sleep-Related Variants Show Low Penetrance in Large Population Analysis

A limited number of variants had documented sleep effects in an investigation in PLOS Genetics of 10 genes with reported sleep ties in nearly 192,000 participants in four population studies.

Researchers Develop Polygenic Risk Scores for Dozens of Disease-Related Exposures

With genetic data from two large population cohorts and summary statistics from prior genome-wide association studies, researchers came up with 27 exposure polygenic risk scores in the American Journal of Human Genetics.