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Praise for Proteomics

The method of the year for 2012 is targeted proteomics, says Methagora, Nature Methods' blog. "Targeted proteomics … offers a tantalizing opportunity to bring a sampling of the power of mass spectrometry to the wider community of biologists," writes Daniel Evanko there. "The assays are simpler, easier to run and well suited to the hypothesis-driven experiments that are the mainstay of biological research."

Evanko notes that proteomic techniques have been around in smaller-scale versions, like as Western blots or immunofluorescence, and targeted mass spectrometry "offers the possibility for thousands of labs to move away from, or supplement, Western blots; and improve the quality and quantity of their protein measurements."

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.