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The Popular Kinases

Much of kinase research has focused on a sliver of the known kinases, and some Canadian researchers have looked into why that is, reports the Physics arXiv Blog at Technology Review. That specific focus by the researchers on just some portion of what could be studied is called the Harlow-Knapp effect, the blog adds. The University of Toronto's Ruth Isserlin and colleagues note in a paper posted to arXiv that even the publication of the human kinome did little to alter researchers' focus away from the best-known kinases. "We posit that the [Harlow-Knapp] effect likely derives from a combination of human nature, the structure of the funding and peer-review systems and the availability of research infrastructure and methods," the authors write.

The Scan

White-Tailed Deer Harbor SARS-CoV-2 Variants No Longer Infecting Humans, Study Finds

A new study in PNAS has found that white-tailed deer could act as a reservoir of SARS-CoV-2 variants no longer found among humans.

Study Points to Benefits of Local Consolidative Therapy, Targeted Treatments in Cancer Care

In JCO Precision Oncology, researchers report that local consolidative therapy combined with molecularly targeted treatments could improve survival for some lung cancer patients.

Genetic Variants That Lower LDL Cholesterol Linked to Reduced Heart Disease Risk

Rare variants in two genes that lower LDL cholesterol are also associated with a decreased risk of coronary heart disease, according to a new JAMA Cardiology study.

Study Links Evolution of Longevity, Social Organization in Mammals

With the help of comparative phylogenetics and transcriptomics, researchers in Nature Communications see ties between lifespan and social organization in mammals.