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The Popular Bacteria

Nick Loman at Pathogens: Genes and Genomes compiled a list of the 50 most sequenced bacteria using NCBI's databases of complete and incomplete genome projects. Topping his list is, no surprise, Escherichia coli, followed by Staphylococcus aureus and Helicobacter pylori. At his own blog, Mike the Mad Biologist adds that the number of genomes sequenced will likely increase quickly. "E. coli will probably triple, S. aureus and Enterococcus will explode many-fold, B. cereus will triple. And this could very well be a large underestimate on my part," Mike writes, adding, "Of course, this then leads to the question of how one goes about analyzing hundreds of genomes."

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.