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Nature News says the Office of Research Integrity's latest attempt at "making research-integrity training more useful and effective" takes the form of an interactive video, called The Lab. This video — which is "soon to be available online, and on DVD for universities that get US federal funding," according to Nature — allows participants the chance to assume the role of one of four characters in a lab in which fraud occurs:

There's the eager young graduate student whose parents keep asking when she'll graduate. There's the overworked postdoc torn between his pregnant wife and his duties in the lab. There's an up-and-coming principal investigator who feels overwhelmed by the demands of his work and his family, but can't stop himself from accepting invitations to speak at even minor conferences. And there's a research integrity officer — the official in charge of looking into suspected cases of misconduct.

Nature says The Lab is "realistic and absorbing depiction of lab life — peppered with references to cultural touchstones," which "makes the video true to life." The four characters' actions in response to scientific fraud also incur realistic consequences: "… even when characters do the 'right' thing, events don't always work out for the best," Nature adds. Catherine Sheely at Johns Hopkins University told Nature that "a lab is … its own little dysfunctional family," and added that ORI's interactive video aptly addresses some of the "personal concerns that come up because of scientific ethical questions."

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.