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Phenotype Reigns Supreme

A new article in Nature Reviews Drug Discovery shows that phenotypic screening accounts for a large number of drug approvals, says In the Pipeline's Derek Lowe. The paper's authors looked back at 259 drugs — 75 first-in-class, 164 followers, and 20 imaging agents — approved between 1999 and 2008, and found that 100 were discovered using a target-based approach and 58 through phenotypic approaches, Lowe says. Of the 75 first-in-class drugs, 28 were assigned to phenotypic assays and only 17 to target-based approaches. "CNS and infectious disease were the therapeutic areas that benefited the most from phenotypic screening, which makes sense. We really don't understand the targets and mechanisms in the former, and the latter provide what are probably the most straightforward and meaningful phenotypic assays in the whole business," Lowe says. The paper's authors concluded that while research on drugs has increasingly focused on targets, this has come at the expense of preclinical assays that "translate more effectively into clinical effects in patients with a specific disease." Lowe agrees, adding, "Will we look back on the late 20th century/early 21st as a target-based detour in drug discovery?"

The Scan

Rise of BA.5

The New York Times reports that the Omicron subvariant BA.5 has become the dominant version of SARS-CoV-2 in the US.

UK Health Secretary Resigns

Sajid Javid, the UK health secretary, resigned along with Chancellor Rishi Sunak, saying they cannot work with Prime Minister Boris Johnson's government, CNN reports.

Clones From Freeze-Dried Cells

A team in Japan has cloned mice from freeze-dried skin cells, according to the Guardian.

Genome Research Papers on Craniosynostosis, Macaque Retrotransposition, More

In Genome Research this week: structural variants in craniosynostosis, LINE-1 activity in rhesus macaque brain, and more.