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A Personalized Medicine Pilot

The Mayo Clinic is starting a pilot study to sequence patients in an effort to personalize their health care, reports Ian Sample at the Guardian. Patients will either have their entire genome, disease-related genes, or drug metabolism-related genes sequenced. "The project will help managers at the clinic decide whether it makes sense to read and store a patient's whole genome early on, instead of ordering single genetic tests as and when the need arises," Sample says.

"With piecemeal genetic testing you only test for what you know. The advantage of whole genome sequencing is that you go after everything," says Gianrico Farrugia, who directs the Mayo Clinic's Center for Individualized Medicine. "Not only does that give you a fuller picture, but it allows you to draw complex interaction pathways that you cannot draw by going after select genes."

The Scan

New Study Highlights Role of Genetics in ADHD

Researchers report in Nature Genetics on differences in genetic architecture between ADHD affecting children versus ADHD that persists into adulthood or is diagnosed in adults.

Study Highlights Pitfall of Large Gene Panels in Clinical Genomic Analysis

An analysis in Genetics in Medicine finds that as gene panels get larger, there is an increased chance of uncovering benign candidate variants.

Single-Cell Atlas of Drosophila Embryogenesis

A new paper in Science presents a single-cell atlas of fruit fly embryonic development over time.

Phage Cocktail Holds Promise for IBD

Researchers uncovered a combination phage therapy that targets Klebsiella pneumonia strains among individuals experiencing inflammatory bowel disease flare ups, as they report in Cell.