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A Peer Review of Peer Review?

A new study in PLoS One statistically analyzes the problem of "widely varying reviews from different referees for the same exact paper," says In the Pipeline's Derek Lowe. The study is a meta-analysis of 52 papers and confirms that "yes, inter-reviewer reliability is low," he adds. Too high a level of agreement between reviewers could also be a problem — some of the reviewers may be redundant, or the pool of reviewers wasn't chosen with care, Lowe adds. So what level of agreement, or disagreement, is best? Well, good luck figuring that one out, Lowe says. Even with a close reading of all reviewer comments on a particular submission, it won't be easy to do.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.