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PCR Vendors, Skip to the Next Post

In a paper published online yesterday in Nature Methods, senior author Richard Gibbs and collaborators at Baylor and NimbleGen present a direct-selection technique for DNA sequences that does not require using PCR. The work took place using NimbleGen arrays and a 454 sequencer. "We combined these new developments to enable the efficient targeted capture and sequencing of specific DNA sequences from complex genomes to provide an alternative to PCR-based methods," the authors write.

 

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.