In Cancer Cell, a paper from The Cancer Genome Atlas Research Network reports that they cataloged recurrent genomic abnormalities in glioblastoma multiforme and were able to classify the tumors into subtypes. Dan Koboldt at MassGenomics explains that the subtypes, proneural, neural, classical, and mesenchymal, were determined by gene expression clustering and specific genetic alterations patterns. When combined with clinical data, other patterns emerged: patients with proneural subtypes were younger and the subtypes responded differently to aggressive therapy. “These findings have important implications for GBM diagnosis and treatment, and also demonstrate the power of the Cancer Genome Atlas: integrating gene expression, mutation, copy number, and clinical data for some of the world’s deadliest cancers,” Koboldt writes.
Parsing Out Types of Glioblastoma
Jan 30, 2010