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Parsing Out Types of Glioblastoma

In Cancer Cell, a paper from The Cancer Genome Atlas Research Network reports that they cataloged recurrent genomic abnormalities in glioblastoma multiforme and were able to classify the tumors into subtypes. Dan Koboldt at MassGenomics explains that the subtypes, proneural, neural, classical, and mesenchymal, were determined by gene expression clustering and specific genetic alterations patterns. When combined with clinical data, other patterns emerged: patients with proneural subtypes were younger and the subtypes responded differently to aggressive therapy. “These findings have important implications for GBM diagnosis and treatment, and also demonstrate the power of the Cancer Genome Atlas: integrating gene expression, mutation, copy number, and clinical data for some of the world’s deadliest cancers,” Koboldt writes.

The Scan

Long COVID-19 Susceptibility Clues Contained in Blood Plasma Proteome

A longitudinal study in eBioMedicine found weeks-long blood plasma proteome shifts after SARS-CoV-2 infection, along with proteomic signatures that appeared to coincide with long Covid risk.

Tibetan Study Finds Adaptive Variant Influencing Skin Pigmentation

With a combination of phenotyping and genetic data, researchers document at PNAS a Tibetan-enriched enhancer variant influencing melanin synthesis and ultraviolet light response.

Domestication Linked to Nervous System Genes in Inbred Mouse Strains

Researchers highlighted more than 300 positively selected genes in domesticated mice, including genes linked to nervous system function or behavior in Genome Biology.

ALS Genetic Testing May Be Informative Across Age Ranges, Study Finds

Researchers in the journal Brain identified clinically actionable variants in a significant subset of older ALS patients, prompting them to point to the potential benefits of broader test use.