The lack of a "revolution" following the Human Genome Project may indicate that researchers are not going about studying the link between genes and disease the right way, says Stephan Hall in this month's Scientific American. Proponents of the project foresaw personalized medicine as a possibility by 2010, but now Hall says "the scientific community finds itself sobered and divided." The dividing question is: do common genetic variants cause disease, or do rare genetic variants?

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