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Or Just Close it Down

After the next round of grant submissions, the US National Heart, Lung, and Blood Institute says it will no longer accept investigator-initiated R21 applications, the agency says. In an announcement, NHLBI says that the point of the R21 grant was to give investigators time and money to produce preliminary data that could then be used to pursue larger studies. "However, the NHLBI has determined that this grant mechanism is not having the effect or the impact on its research grant portfolio in the manner for which it was originally intended," the agency says, adding that it is suspending the program, though it may fund targeted R21 requests. At his blog, DrugMonkey points out that NHLBI did not say anything about why the program was not having the desired effect. "If you have a desired goal, and the thing you thought would accomplish that goal isn't getting the job done, you might want to fix or replace it. Otherwise someone might conclude you aren't really interested in the goal in the first place," he writes.

The Scan

Alzheimer's Risk Gene Among Women

CNN reports that researchers have found that variants in MGMT contribute to Alzheimer's disease risk among women but not men.

Still Hanging Around

The Guardian writes that persistent pockets of SARS-CoV-2 in the body could contribute to long COVID.

Through a Little Spit

Enteric viruses like norovirus may also be transmitted through saliva, not just the fecal-oral route, according to New Scientist.

Nature Papers Present Method to Detect Full Transcriptome, Viruses Infecting Asgard Archaea, More

In Nature this week: VASA-seq approach to detect full transcriptome, analysis of viruses infecting Asgard archaea, and more.