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The Odds of a Funded Grant

The overall success rate of getting an NIH grant funded in 2009 was 20.6 percent, reports Writedit at Medical Writing, Editing & Grantsmanship. She breaks the data down further to find that R21s have success rates below those of R01s and lists grant success rates for R21s at some of the major institutes: 14.5 percent at NHLBI, 13.7 percent at NCI, and 7.9 percent at NIGMS. NIMH has a high R21 success rate, coming in at 20.1 percent. "In general, in fact, NIMH looks to be a nice place to go for money … except for R03s, which have a success rate of 9.6%," she writes.

The Scan

Researchers Compare WGS, Exome Sequencing-Based Mendelian Disease Diagnosis

Investigators find a diagnostic edge for whole-genome sequencing, while highlighting the cost advantages and improving diagnostic rate of exome sequencing in EJHG.

Researchers Retrace Key Mutations in Reassorted H1N1 Swine Flu Virus With Avian-Like Features

Mutations in the acidic polymerase-coding gene boost the pathogenicity and transmissibility of Eurasian avian-like H1N1 swine influenza viruses, a PNAS paper finds.

Genome Sequences Reveal Evolutionary History of South America's Canids

An analysis in PNAS of South American canid species' genomes offers a look at their evolutionary history, as well as their relationships and adaptations.

Lung Cancer Response to Checkpoint Inhibitors Reflected in Circulating Tumor DNA

In non-small cell lung cancer patients, researchers find in JCO Precision Oncology that survival benefits after immune checkpoint blockade coincide with a dip in ctDNA levels.