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Obesity Links

From a meta-analysis of 14 genome-wide association study datasets, a team led by researchers from Children's Hospital of Philadelphia found two new loci linked to childhood obesity. As the team reports in Nature Genetics, they examined 2.7 million SNPs at seven loci that had previously been linked to adult body mass index. One new locus is near OLFM4 and the other is within HOXB5. "We see a clear genetic signature to childhood obesity, showing there is more than just an environmental component to this disease," CHOP's Struan Grant tells LiveScience. In their paper, the researchers note that functional characterization of the signals to determine the mechanisms through which they work is still needed.

The Scan

Fertility Fraud Found

Consumer genetic testing has uncovered cases of fertility fraud that are leading to lawsuits, according to USA Today.

Ties Between Vigorous Exercise, ALS in Genetically At-Risk People

Regular strenuous exercise could contribute to motor neuron disease development among those already at genetic risk, Sky News reports.

Test Warning

The Guardian writes that the US regulators have warned against using a rapid COVID-19 test that is a key part of mass testing in the UK.

Science Papers Examine Feedback Mechanism Affecting Xist, Continuous Health Monitoring for Precision Medicine

In Science this week: analysis of cis confinement of the X-inactive specific transcript, and more.